Many patients experience immediate pain relief from the local anesthetic within minutes of receiving trigger point injections. This initial relief may last several hours to days. The full therapeutic benefit typically develops over 24-72 hours as inflammation decreases and muscle tension releases. If corticosteroids are included, anti-inflammatory effects peak around 3-7 days post-injection. Some patients require 2-3 treatment sessions before experiencing optimal results, as chronic trigger points may need repeated treatment to fully resolve.